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SYNAPSIN II
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DeCS
Descriptor
English
:
Synapsins
Descriptor
Spanish
:
Sinapsinas
Descriptor
Portuguese
:
Sinapsinas
Synonyms
English
:
Synapsin I
Synapsin II
Synapsin III
Tree Number:
D12.776.631.750
D12.776.744.840
Definition
English
:
A
family
of synaptic vesicle-associated
proteins
involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this
family
, links
SYNAPTIC VESICLES
to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible
PHOSPHORYLATION
of synapsin I through various
signal transduction
pathways. The protein is also a substrate for cAMP- and
CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES
. It is believed that these functional properties are also
shared
by synapsin II.
History Note
English
:
1992; use SYNAPSINS (NM) 1981-1991
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
29796
Unique Identifier:
D016704
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS